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Ernest Puil, PhD
Anesthesiology, Pharmacology & Therapeutics
Faculty of Medicine
University of British Columbia
Prof. Puil is a Professor Emeritus in the UBC Department of Anesthesiology, Pharmacology & Therapeutics. With colleagues (MacLeod et al. 2010), he discovered a novel first-in-class analgesic prototype isovaline. He pioneered research demonstrating how membrane properties of neurons interact to amplify inputs through resonant behavior. He has a long-standing interest in a neurophysiological basis of neurotransmission (such as in pain). In 2006, with colleagues he demonstrated a neurotransmitter role for glycine in the thalamus (Ghavanini et al.). His Research Interests include: central nervous system physiology and pharmacology, cellular basis of awareness and sleep, synaptic communication and neuromodulation in the brain, and intracellular recording, neuronal modelling, voltage- and patch-clamp analysis of neurons in the brain.
Reserach Keywords: pharmacology, analgesics, pain, neurotransmitters